FE65 anticorps (AA 361-710)
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- Antigène Voir toutes FE65 (APBB1) Anticorps
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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Épitope
- AA 361-710
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FE65 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)
- Isotype
- IgG
- Top Product
- Discover our top product APBB1 Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
- Autre désignation
- APBB1 (APBB1 Produits)
- Synonymes
- anticorps FE65, anticorps MGC:9072, anticorps RIR, anticorps apbb1, anticorps MGC80654, anticorps Fe65, anticorps Rir, anticorps amyloid beta precursor protein binding family B member 1, anticorps amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog, anticorps amyloid beta (A4) precursor protein-binding, family B, member 1, anticorps APBB1, anticorps apbb1.L, anticorps Apbb1
- Sujet
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Background: Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on \\\'Tyr-142\\\' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Aliases: Adaptor protein FE65a2 antibody, Amyloid beta (A4) precursor protein binding family B member 1 antibody, Amyloid beta A4 precursor protein binding family B antibody, Amyloid beta A4 precursor protein binding family B member 1 antibody, Amyloid beta A4 precursor protein-binding family B member 1 antibody, Amyloid beta precursor protein binding family B member 1 antibody, APBB 1 antibody, APBB1 antibody, APBB1_HUMAN antibody, FE 65 antibody, Fe65 protein antibody, Protein Fe65 antibody, RIR antibody, stat like protein antibody
- UniProt
- O00213
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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