TAP1 anticorps (AA 524-808)
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- Antigène Voir toutes TAP1 Anticorps
- TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))
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Épitope
- AA 524-808
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAP1 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human Antigen peptide transporter 1 protein (524-808AA)
- Isotype
- IgG
- Top Product
- Discover our top product TAP1 Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- TAP1 (Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP1))
- Autre désignation
- TAP1 (TAP1 Produits)
- Synonymes
- anticorps ABC17, anticorps ABCB2, anticorps APT1, anticorps D6S114E, anticorps PSF-1, anticorps PSF1, anticorps RING4, anticorps TAP1*0102N, anticorps TAP1N, anticorps abc17, anticorps abcb2, anticorps apt1, anticorps psf1, anticorps ring4, anticorps tap1a, anticorps tap1n, anticorps Abcb2, anticorps Ham-1, anticorps Ham1, anticorps MTP1, anticorps TAP, anticorps Tap-1, anticorps Y3, anticorps Cim, anticorps transporter 1, ATP binding cassette subfamily B member, anticorps transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) L homeolog, anticorps transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), anticorps TAP1, anticorps tap1.L, anticorps Tap1
- Sujet
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Background: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Aliases: ABC 17 antibody, ABC transporter MHC 1 antibody, ABC17 antibody, ABCB 2 antibody, ABCB2 antibody, Antigen peptide transporter 1 antibody, APT 1 antibody, APT1 antibody, ATP binding cassette sub family B (MDR/TAP) member 2 antibody, ATP binding cassette sub family B member 2 antibody, ATP binding cassette transporter antibody, ATP-binding cassette sub-family B member 2 antibody, D6S114E antibody, FLJ26666 antibody, FLJ41500 antibody, Peptide supply factor 1 antibody, Peptide transporter involved in antigen processing 1 antibody, Peptide transporter PSF 1 antibody, Peptide transporter PSF1 antibody, Peptide transporter TAP 1 antibody, Peptide transporter TAP1 antibody, PSF 1 antibody, PSF-1 antibody, PSF1 antibody, Really interesting new gene 4 protein antibody, RING 4 antibody, RING4 antibody, TAP 1 antibody, TAP1 antibody, TAP1*0102N antibody, TAP1_HUMAN antibody, TAP1N antibody, Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody, Transporter 1 ATP binding cassette sub family B antibody, Transporter associated with antigen processing antibody, Transporter ATP binding cassette major histocompatibility complex 1 antibody, Y3 antibody
- UniProt
- Q03518
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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