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PYCARD anticorps (AA 1-195)

PYCARD Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7144464
  • Antigène Voir toutes PYCARD Anticorps
    PYCARD (PYD and CARD Domain Containing (PYCARD))
    Épitope
    • 10
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-195
    Reactivité
    • 56
    • 10
    • 9
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 47
    • 7
    • 3
    Lapin
    Clonalité
    • 46
    • 11
    Polyclonal
    Conjugué
    • 32
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PYCARD est non-conjugé
    Application
    • 39
    • 22
    • 14
    • 13
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
     Réactivité croisée
    Humain, Souris
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Apoptosis-associated speck-like protein containing a CARD protein (1-195AA)
    Isotype
    IgG
    Top Product
    Discover our top product PYCARD Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:1000-1:5000, IHC:1:500-1:1000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PYCARD (PYD and CARD Domain Containing (PYCARD))
    Autre désignation
    PYCARD (PYCARD Produits)
    Synonymes
    anticorps ASC, anticorps CARD5, anticorps TMS, anticorps TMS-1, anticorps TMS1, anticorps 9130417A21Rik, anticorps Asc, anticorps TNS1, anticorps masc, anticorps asc1, anticorps zAsc, anticorps zgc:109874, anticorps PYD and CARD domain containing, anticorps PYCARD, anticorps Pycard, anticorps pycard
    Sujet

    Background: Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. Isoform 2 may have a regulating effect on the function as inflammasome adapter. Isoform 3 seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2, the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome, this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating MB21D1 in presence of cytoplasmic double-stranded DNA (PubMed:28314590).

    Aliases: Apoptosis associated speck like protein containing a CARD antibody, Apoptosis-associated speck-like protein containing a CARD antibody, ASC antibody, ASC_HUMAN antibody, CARD 5 antibody, CARD5 antibody, Caspase recruitment domain containing protein 5 antibody, Caspase recruitment domain protein 5 antibody, Caspase recruitment domain-containing protein 5 antibody, hASC antibody, MGC10332 antibody, PYCARD antibody, PYD and CARD domain containing antibody, PYD and CARD domain containing protein antibody, PYD and CARD domain-containing protein antibody, Target of methylation induced silencing 1 antibody, Target of methylation-induced silencing 1 antibody, TMS 1 antibody, TMS antibody, TMS1 antibody

    UniProt
    Q9ULZ3
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome
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