MAPK7 anticorps (pSer496)

N° du produit ABIN710246

Détail du produit anti-MAPK7 anticorps

Antigène: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Épitope: pSer496

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPK7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation site of Ser496 [GP(p-S)AP]

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-MAPK7 (ABIN710246)

Zhuang, Zhang, Xiong, Wang, Luo, Han, Meng, Zhang, Liao, Liu: "CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5-AP-1 axis." dans: Cell death & disease, Vol. 7, Issue 10, pp. e2415, (2017) (PubMed).

Détails sur MAPK7

Antigène: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Autre désignation: ERK5 (MAPK7 Produits)

Synonymes: anticorps BMK1, anticorps ERK4, anticorps ERK5, anticorps PRKM7, anticorps Erk5-T, anticorps ATMPK7, anticorps F8D23.5, anticorps F8D23_5, anticorps MAP kinase 7, anticorps Bmk1, anticorps Erk5, anticorps Prkm7, anticorps ERK-5, anticorps bmk1, anticorps erk4, anticorps mapk7, anticorps prkm7, anticorps mitogen-activated protein kinase 7, anticorps MAP kinase 7, anticorps mitogen-activated protein kinase 7 L homeolog, anticorps MAPK7, anticorps Mapk7, anticorps MPK7, anticorps mapk7.L

Sujet:

Synonyms: BMK1, ERK4, ERK5, PRKM7, Mitogen-activated protein kinase 7, MAP kinase 7, MAPK 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5, MAPK7

Background: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

ID gène: 5598

UniProt: Q13164

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling