Asporin anticorps (AA 33-380)

N° du produit ABIN7144761

Détail du produit anti-Asporin anticorps

Antigène: Asporin (ASPN)

Épitope: AA 33-380

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Asporin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Asporin protein (33-380AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Asporin

Antigène: Asporin (ASPN)

Autre désignation: ASPN (ASPN Produits)

Synonymes: anticorps OS3, anticorps PLAP-1, anticorps PLAP1, anticorps SLRR1C, anticorps bgl3, anticorps aspnl, anticorps wu:fk08c11, anticorps zgc:109936, anticorps 4631401G09Rik, anticorps AA986886, anticorps Plap1, anticorps Slrr1c, anticorps os3, anticorps plap-1, anticorps plap1, anticorps slrr1c, anticorps asporin, anticorps asporin (LRR class 1), anticorps asporin L homeolog, anticorps ASPN, anticorps aspn, anticorps Aspn, anticorps aspn.L

Sujet:

Background: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

Aliases: ASPN antibody, ASPN protein antibody, ASPN_HUMAN antibody, Asporin (LRR class 1) antibody, Asporin antibody, Asporin proteoglycan antibody, FLJ20129 antibody, LRR class 1 antibody, Periodontal ligament associated protein 1 antibody, Periodontal ligament-associated protein 1 antibody, PLAP 1 antibody, PLAP-1 antibody, PLAP1 antibody, SLRR 1C antibody, SLRR1C antibody, Small leucine rich protein 1C antibody

UniProt: Q9BXN1