NAIP anticorps (AA 147-242)

N° du produit ABIN7145194

Détail du produit anti-NAIP anticorps

Antigène: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Épitope: AA 147-242

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAIP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Baculoviral IAP repeat-containing protein 1 protein (147-242AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NAIP

Antigène: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Autre désignation: NAIP (NAIP Produits)

Synonymes: anticorps BIRC1, anticorps NLRB1, anticorps psiNAIP, anticorps AV364616, anticorps Birc1a, anticorps D13Lsd1, anticorps Naip, anticorps Naip-rs1, anticorps NLR family apoptosis inhibitory protein, anticorps NLR family, apoptosis inhibitory protein 1, anticorps NAIP, anticorps Naip1

Sujet:

Background: \\\"Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at \\\'Asp-315\\\' and decreasing the rate of auto proteolysis at \\\'Asp-330\\\'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.\\\"

Aliases: Baculoviral IAP repeat containing 1 antibody, Baculoviral IAP repeat-containing protein 1 antibody, BIRC 1 antibody, BIRC1 antibody, BIRC1_HUMAN antibody, Birc1a antibody, FLJ42520 antibody, NAIP antibody, Naip1 antibody, Neuronal apoptosis inhibitory protein antibody, NLR family apoptosis inhibitory protein antibody, NLR family BIR domain containing 1 antibody, NLRB 1 antibody, NLRB1 antibody, Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody, Psi neuronal apoptosis inhibitory protein antibody, psiNAIP antibody, Similar to occludin antibody

UniProt: Q13075

Pathways: Apoptose, Inflammasome