BARD1 anticorps (AA 428-777) (Biotin)

N° du produit ABIN7145763

Détail du produit anti-BARD1 anticorps (Biotin)

Antigène: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Épitope: AA 428-777

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BARD1 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human BRCA1-associated RING domain protein 1 protein (428-777AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BARD1

Antigène: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Autre désignation: BARD1 (BARD1 Produits)

Synonymes: anticorps BARD1, anticorps LOC100147913, anticorps ENSMUSG00000060893, anticorps ENSMUSG00000073653, anticorps BRCA1 associated RING domain 1, anticorps BARD1, anticorps bard1, anticorps Bard1

Sujet:

Background: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of \'Lys-6\'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3\' cleavage.

Aliases: BARD-1 antibody, Bard1 antibody, BARD1_HUMAN antibody, BRCA1 associated RING domain 1 antibody, BRCA1 associated RING domain gene 1 antibody, BRCA1 associated RING domain protein 1 antibody, BRCA1-associated RING domain protein 1 antibody

UniProt: Q99728

Pathways: Réparation de l'ADN