BRE anticorps (AA 94-383) (HRP)
-
- Antigène Voir toutes BRE Anticorps
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
-
Épitope
- AA 94-383
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp BRE est conjugé à/à la HRP
-
Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human BRISC and BRCA1-A complex member 2 protein (94-383AA)
- Isotype
- IgG
- Top Product
- Discover our top product BRE Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Antigène
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- Autre désignation
- BABAM2 (BRE Produits)
- Synonymes
- anticorps brcc4, anticorps brcc45, anticorps BRE, anticorps LOC100231620, anticorps BRCC4, anticorps BRCC45, anticorps 6030405P19Rik, anticorps AI429776, anticorps B830038C02Rik, anticorps im:7141046, anticorps zgc:110368, anticorps BRISC and BRCA1 A complex member 2, anticorps brain and reproductive organ-expressed (TNFRSF1A modulator), anticorps BRISC and BRCA1 A complex member 2 L homeolog, anticorps babam2, anticorps BABAM2, anticorps Babam2, anticorps BRE, anticorps babam2.L
- Sujet
-
Background: Component of the BRCA1-A complex, a complex that specifically recognizes \'Lys-63\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes \'Lys-63\'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves \'Lys-63\'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect (PubMed:15465831).
Aliases: 6030405P19Rik antibody, AI429776 antibody, B830038C02Rik antibody, Brain and reproductive organ expressed (TNFRSF1A modulator) antibody, brain and reproductive organ expressed protein antibody, Brain and reproductive organ-expressed protein antibody, BRCA1 A complex subunit BRE antibody, BRCA1-A complex subunit BRE antibody, BRCA1/BRCA2 containing complex subunit 4 antibody, BRCA1/BRCA2 containing complex subunit 45 antibody, BRCA1/BRCA2-containing complex subunit 45 antibody, BRCC4 antibody, BRCC45 antibody, bre antibody, BRE_HUMAN antibody
- UniProt
- Q9NXR7
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
-