MICU1 anticorps (AA 55-191) (Biotin)

N° du produit ABIN7146323

Détail du produit anti-MICU1 anticorps (Biotin)

Antigène: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Épitope: AA 55-191

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MICU1 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MICU1

Antigène: MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))

Autre désignation: MICU1 (MICU1 Produits)

Synonymes: anticorps CALC, anticorps CBARA1, anticorps EFHA3, anticorps C730016L05Rik, anticorps Calc, anticorps Cbara1, anticorps mitochondrial calcium uptake 1, anticorps MICU1, anticorps Micu1

Sujet:

Background: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Aliases: Allergen Hom s 4 antibody, ara CALC antibody, atopy related autoantigen antibody, atopy related autoantigen CALC antibody, Atopy-related autoantigen CALC antibody, CALC antibody, calcium binding atopy related autoantigen 1 antibody, Calcium uptake protein 1 antibody, calcium uptake protein 1, mitochondrial antibody, Calcium-binding atopy-related autoantigen 1 antibody, CBARA1 antibody, EFHA3 antibody, FLJ12684 antibody, MICU1 antibody, MICU1_HUMAN antibody, mitochondrial antibody, mitochondrial calcium uptake 1 antibody, MPXPS antibody

UniProt: Q9BPX6