Caspase 8 anticorps (AA 217-374)

N° du produit ABIN7146964

Détail du produit anti-Caspase 8 anticorps

Antigène: Caspase 8 (CASP8)

Épitope: AA 217-374

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Caspase-8 protein (217-374AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:10-1:100, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: CASP8 (CASP8 Produits)

Synonymes: anticorps casp8-A, anticorps xCaspase-8, anticorps casp8, anticorps CASP8, anticorps CASP-8, anticorps FLICE, anticorps MACH, anticorps Mch5, anticorps ALPS2B, anticorps CAP4, anticorps Casp-8, anticorps MCH5, anticorps caspase-8, anticorps zgc:92075, anticorps caspase 8 L homeolog, anticorps death related ced-3/Nedd2-like protein, anticorps caspase 8, anticorps caspase-8, anticorps caspase-8-like, anticorps caspase 8, apoptosis-related cysteine peptidase, anticorps casp8.L, anticorps LOC661095, anticorps CASP8, anticorps LOC5563818, anticorps casp8, anticorps LOC100222284, anticorps Casp8

Sujet:

Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Aliases: ALPS2B antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody, Apoptosis related cysteine peptidase antibody, Apoptotic cysteine protease antibody, Apoptotic protease Mch-5 antibody, Apoptotic protease Mch5 antibody, CAP 4 antibody, CAP4 antibody, CASP-8 antibody, CASP8 antibody, CASP8_HUMAN antibody, Caspase 8 antibody, Caspase 8 apoptosis related cysteine peptidase antibody, Caspase IIX antibody, Caspase-8 subunit p10 antibody, caspase8 antibody, CED 3 antibody, FADD Homologous ICE/CED3 Like Protease antibody, FADD Like ICE antibody, FADD-homologous ICE/CED-3-like protease antibody, FADD-like ICE antibody, FLICE antibody, FLJ17672 antibody, ICE-like apoptotic protease 5 antibody, MACH alpha 1/2/3 protein antibody, MACH antibody, MACH beta 1/2/3/4 protein antibody, MACH5 antibody, MCH 5 antibody, MCH5 antibody, MGC78473 antibody, MORT1 associated ced 3 homolog antibody, MORT1 associated CED3 homolog antibody, MORT1-associated CED-3 homolog antibody, OTTHUMP00000163717 antibody, OTTHUMP00000163720 antibody, OTTHUMP00000163724 antibody, OTTHUMP00000163725 antibody, OTTHUMP00000165062 antibody, OTTHUMP00000165063 antibody, OTTHUMP00000165064 antibody, OTTHUMP00000206552 antibody, OTTHUMP00000206582 antibody

UniProt: Q14790

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades