CHMP1A anticorps (AA 1-196) (Biotin)

N° du produit ABIN7147515

Détail du produit anti-CHMP1A anticorps (Biotin)

Antigène: CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))

Épitope: AA 1-196

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP1A est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Charged multivesicular body protein 1a protein (1-196AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHMP1A

Antigène: CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))

Autre désignation: CHMP1A (CHMP1A Produits)

Synonymes: anticorps CHMP1, anticorps PCH8, anticorps PCOLN3, anticorps PRSM1, anticorps VPS46-1, anticorps VPS46A, anticorps 2900018H07Rik, anticorps Pcoln3, anticorps charged multivesicular body protein 1A, anticorps CHMP1A, anticorps Chmp1a

Sujet:

Background: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Aliases: Charged multivesicular body protein 1a antibody, CHM1A_HUMAN antibody, CHMP1a antibody, Chromatin modifying protein 1a antibody, Chromatin-modifying protein 1a antibody, hVps46 1 antibody, hVps46-1 antibody, KIAA0047 antibody, Metalloprotease 1 antibody, PCOLN3 antibody, Procollagen (type III) N endopeptidase antibody, PRSM1 antibody, Vacuolar protein sorting 46 1 antibody, Vacuolar protein sorting-associated protein 46-1 antibody, Vps46 1 antibody, Vps46-1 antibody

UniProt: Q9HD42