HUS1 anticorps (AA 2-280) (HRP)

N° du produit ABIN7147544

Détail du produit anti-HUS1 anticorps (HRP)

Antigène: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Épitope: AA 2-280

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUS1 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Checkpoint protein HUS1 protein (2-280AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HUS1

Antigène: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Autre désignation: HUS1 (HUS1 Produits)

Synonymes: anticorps hHUS1, anticorps mHus1, anticorps XHus1, anticorps hus1, anticorps HUS1 checkpoint clamp component, anticorps checkpoint clamp complex protein Hus1, anticorps HUS1 checkpoint clamp component L homeolog, anticorps HUS1, anticorps Hus1, anticorps hus1, anticorps hus1.L

Sujet:

Background: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.

Aliases: Checkpoint protein HUS1 antibody, hHUS1 antibody, HUS1 (S. pombe) checkpoint homolog antibody, Hus1 antibody, HUS1 checkpoint homolog (S. pombe) antibody, HUS1 Checkpoint Protein antibody, HUS1 protein antibody, HUS1+ - like protein antibody, HUS1_HUMAN antibody, Hydroxyurea-sensitive 1, S. pombe, homolog of antibody

UniProt: O60921