BHLHE41 anticorps (AA 185-285) (Biotin)

N° du produit ABIN7147842

Détail du produit anti-BHLHE41 anticorps (Biotin)

Antigène: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Épitope: AA 185-285

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BHLHE41 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BHLHE41

Antigène: BHLHE41 (Basic Helix-Loop-Helix Family, Member E41 (BHLHE41))

Autre désignation: BHLHE41 (BHLHE41 Produits)

Synonymes: anticorps BHLHB3, anticorps dec2, anticorps bhlhb3, anticorps sharp1, anticorps sharp-1, anticorps MGC108143, anticorps DEC2, anticorps SHARP1, anticorps hDEC2, anticorps 6430520M22Rik, anticorps Bhlhb2l, anticorps Bhlhb3, anticorps Sharp1, anticorps Dec2, anticorps SHARP-1, anticorps basic helix-loop-helix family member e41, anticorps basic helix-loop-helix family, member e41, anticorps BHLHE41, anticorps bhlhe41, anticorps Bhlhe41

Sujet:

Background: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5\'-CACGTG-3\') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Aliases: Basic helix-loop-helix domain containing class B3 antibody, BHE41_HUMAN antibody, bHLH protein DEC2 antibody, bHLHB3 antibody, bHLHe41 antibody, Class B basic helix loop helix protein 3 antibody, Class B basic helix-loop-helix protein 3 antibody, Class E basic helix-loop-helix protein 41 antibody, DEC2 antibody, Differentially expressed in chondrocytes protein 2 antibody, Enhancer of split and hairy related protein 1 antibody, Enhancer-of-split and hairy-related protein 1 antibody, hDEC2 antibody, Moderately similar to basic-helix loop helix protein M.musculus antibody, SHARP-1 antibody

UniProt: Q9C0J9

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development