MCC anticorps (AA 479-611) (Biotin)
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- Antigène Voir toutes MCC Anticorps
- MCC (Mutated in Colorectal Cancers (MCC))
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Épitope
- AA 479-611
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MCC est conjugé à/à la Biotin
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Colorectal mutant cancer protein (479-611AA)
- Isotype
- IgG
- Top Product
- Discover our top product MCC Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- MCC (Mutated in Colorectal Cancers (MCC))
- Autre désignation
- MCC (MCC Produits)
- Synonymes
- anticorps MCC, anticorps mcc1, anticorps MCC1, anticorps D18Ertd451e, anticorps E330037C19, anticorps RGD1561988, anticorps mutated in colorectal cancers, anticorps MCC, anticorps mcc, anticorps Mcc
- Sujet
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Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody
- UniProt
- P23508
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