H2AFY anticorps (AA 123-372)

N° du produit ABIN7148560

Détail du produit anti-H2AFY anticorps

Antigène: H2AFY (H2A Histone Family, Member Y (H2AFY))

Épitope: AA 123-372

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp H2AFY est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Core histone macro-H2A.1 protein (123-372AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur H2AFY

Antigène: H2AFY (H2A Histone Family, Member Y (H2AFY))

Autre désignation: H2AFY (H2AFY Produits)

Synonymes: anticorps H2A.y, anticorps H2A/y, anticorps H2AF12M, anticorps H2AFJ, anticorps MACROH2A1.1, anticorps mH2A1, anticorps macroH2A1.2, anticorps mH2a1, anticorps macroH2A1, anticorps wu:fa93c12, anticorps zgc:136891, anticorps h2a.y, anticorps h2a/y, anticorps h2af12m, anticorps h2afj, anticorps macroh2a, anticorps mh2a1, anticorps core histone macro-H2A.1, anticorps H2A histone family, member Y, anticorps H2A histone family member Y, anticorps H2A histone family member Y L homeolog, anticorps LOC100230612, anticorps H2AFY, anticorps LOC481514, anticorps H2afy, anticorps h2afy, anticorps h2afy.L

Sujet:

Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

Aliases: Core histone macro h2a.1 antibody, Core histone macro-H2A.1 antibody, H2A histone family member Y antibody, H2A.y antibody, H2A/y antibody, H2AF12M antibody, H2AFJ antibody, H2afy antibody, H2AY_HUMAN antibody, Histone H2A.Y antibody, Histone macroH2A1 antibody, Histone macroH2A1.1 antibody, Histone macroH2A1.2 antibody, Macroh2a1 antibody, MACROH2A1.1 antibody, MacroH2A1.2 antibody, Medulloblastoma antigen MU MB 50.205 antibody, Medulloblastoma antigen MU-MB-50.205 antibody, mH2a antibody, mH2A1 antibody

UniProt: O75367