DACH1 anticorps (AA 166-369)

N° du produit ABIN7149476

Détail du produit anti-DACH1 anticorps

Antigène: DACH1 (Dachshund 1 (DACH1))

Épitope: AA 166-369

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DACH1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Dachshund homolog 1 protein (166-369AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DACH1

Antigène: DACH1 (Dachshund 1 (DACH1))

Autre désignation: DACH1 (DACH1 Produits)

Synonymes: anticorps DACH, anticorps AI182278, anticorps Dac, anticorps Dach, anticorps E130112M23Rik, anticorps dach, anticorps dachshund family transcription factor 1, anticorps dachshund 1 (Drosophila), anticorps dachshund family transcription factor 1 S homeolog, anticorps dachshund homolog 1, anticorps DACH1, anticorps Dach1, anticorps dach1.S, anticorps dach1, anticorps LOC100550020

Sujet:

Background: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Aliases: DACH antibody, Dach1 antibody, DACH1_HUMAN antibody, Dachshund family transcription factor 1 antibody, dachshund homolog 1 (Drosophila) antibody, Dachshund homolog 1 antibody, Dachsund homolog 1 antibody, FLJ10138 antibody, OTTHUMP00000018494 antibody

UniProt: Q9UI36

Pathways: Feeding Behaviour