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DPPA3 anticorps (AA 1-159) (Biotin)

DPPA3 Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7149821
  • Antigène Voir toutes DPPA3 Anticorps
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    Épitope
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-159
    Reactivité
    • 19
    • 12
    • 1
    • 1
    Humain
    Hôte
    • 20
    • 1
    • 1
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DPPA3 est conjugé à/à la Biotin
    Application
    • 9
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Developmental pluripotency-associated protein 3 protein (1-159AA)
    Isotype
    IgG
    Top Product
    Discover our top product DPPA3 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    Autre désignation
    DPPA3 (DPPA3 Produits)
    Synonymes
    anticorps STELLA, anticorps 2410075G02Rik, anticorps PCG7, anticorps PGC7, anticorps Stella, anticorps developmental pluripotency associated 3, anticorps developmental pluripotency-associated 3, anticorps DPPA3, anticorps Dppa3
    Sujet

    Background: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at \'Lys-9\' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

    Aliases: Compaction associated protein 1 antibody, Developmental pluripotency associated 3 antibody, Developmental pluripotency associated protein 3 antibody, Developmental pluripotency-associated protein 3 antibody, Dppa3 antibody, DPPA3_HUMAN antibody, PGC7 antibody, Stella related protein antibody, Stella-related protein antibody

    UniProt
    Q6W0C5
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