DPPA3 anticorps (AA 1-159) (Biotin)

N° du produit ABIN7149821

Détail du produit anti-DPPA3 anticorps (Biotin)

Antigène: DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Épitope: AA 1-159

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPPA3 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Developmental pluripotency-associated protein 3 protein (1-159AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DPPA3

Antigène: DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Autre désignation: DPPA3 (DPPA3 Produits)

Synonymes: anticorps STELLA, anticorps 2410075G02Rik, anticorps PCG7, anticorps PGC7, anticorps Stella, anticorps developmental pluripotency associated 3, anticorps developmental pluripotency-associated 3, anticorps DPPA3, anticorps Dppa3

Sujet:

Background: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at \'Lys-9\' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

Aliases: Compaction associated protein 1 antibody, Developmental pluripotency associated 3 antibody, Developmental pluripotency associated protein 3 antibody, Developmental pluripotency-associated protein 3 antibody, Dppa3 antibody, DPPA3_HUMAN antibody, PGC7 antibody, Stella related protein antibody, Stella-related protein antibody

UniProt: Q6W0C5