DLG5 anticorps (AA 1580-1704)

N° du produit ABIN7150080

Détail du produit anti-DLG5 anticorps

Antigène: DLG5 (Discs, Large Homolog 5 (DLG5))

Épitope: AA 1580-1704

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DLG5 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Disks large homolog 5 protein (1580-1704AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DLG5

Antigène: DLG5 (Discs, Large Homolog 5 (DLG5))

Autre désignation: DLG5 (DLG5 Produits)

Synonymes: anticorps DLG5, anticorps dlg5, anticorps wu:fc28f03, anticorps LP-DLG, anticorps P-DLG5, anticorps PDLG, anticorps 4933429D20Rik, anticorps T25557, anticorps mKIAA0583, anticorps discs large MAGUK scaffold protein 5, anticorps discs, large homolog 5 (Drosophila), anticorps discs, large homolog 5a (Drosophila), anticorps DLG5, anticorps dlg5a, anticorps Dlg5

Sujet:

Background: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons, regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Aliases: Discs large homolog 5 (Drosophila) antibody, Discs large homolog 5 antibody, Discs large protein LP DLG antibody, Discs large protein P dlg antibody, Discs large protein P-dlg antibody, Disks large homolog 5 antibody, DLG 5 antibody, DLG5 antibody, DLG5_HUMAN antibody, KIAA0583 antibody, Large type of P DLG antibody, LP DLG antibody, P DLG5 antibody, PDLG antibody, Placenta and prostate DLG antibody

UniProt: Q8TDM6