DISC1 anticorps (AA 99-325)

N° du produit ABIN7150092

Détail du produit anti-DISC1 anticorps

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Épitope: AA 99-325

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DISC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DISC1

Antigène: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Autre désignation: DISC1 (DISC1 Produits)

Synonymes: anticorps DISC1, anticorps C1orf136, anticorps SCZD9, anticorps disrupted in schizophrenia 1, anticorps disrupted in schizophrenia 1 protein, anticorps disc1, anticorps DISC1, anticorps LOC100580606, anticorps Disc1

Sujet:

Background: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Aliases: C1orf136 antibody, DISC1 antibody, DISC1_HUMAN antibody, Disrupted in schizophrenia 1 antibody, Disrupted in schizophrenia 1 protein antibody, KIAA0457 antibody, RP4-730B13.1 antibody, SCZD9 antibody

UniProt: Q9NRI5

Pathways: Regulation of Cell Size