ZRANB3 anticorps (AA 370-624)

N° du produit ABIN7150120

Détail du produit anti-ZRANB3 anticorps

Antigène: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Épitope: AA 370-624

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZRANB3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ZRANB3

Antigène: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Autre désignation: ZRANB3 (ZRANB3 Produits)

Synonymes: anticorps 4933425L19Rik, anticorps AH2, anticorps AI316834, anticorps C730006D09, anticorps zinc finger RANBP2-type containing 3, anticorps zinc finger, RAN-binding domain containing 3, anticorps ZRANB3, anticorps Zranb3

Sujet:

Background: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3\\\'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Aliases: 4933425L19Rik antibody, AH2 antibody, Annealing helicase 2 antibody, DNA annealing helicase and endonuclease ZRANB3 antibody, MGC105033 antibody, MGC75012 antibody, OTTHUMP00000197449 antibody, Zinc finger Ran-binding domain-containing protein 3 antibody, Zinc finger, RAN- binding domain containing 3 antibody, ZRAB3_HUMAN antibody, Zranb3 antibody

UniProt: Q5FWF4