DDB1 anticorps (AA 741-943)

N° du produit ABIN7150124

Détail du produit anti-DDB1 anticorps

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Épitope: AA 741-943

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human DNA damage-binding protein 1 protein (741-943AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DDB1

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Autre désignation: DDB1 (DDB1 Produits)

Synonymes: anticorps DDBA, anticorps UV-DDB1, anticorps XAP1, anticorps XPCE, anticorps XPE, anticorps XPE-BF, anticorps DDB1, anticorps xpe, anticorps ddba, anticorps xap1, anticorps xpce, anticorps xpe-bf, anticorps uv-ddb1, anticorps ddb1, anticorps 127kDa, anticorps AA408517, anticorps p127-Ddb1, anticorps damage specific DNA binding protein 1, anticorps damage-specific DNA binding protein 1, 127kDa, anticorps DNA damage-binding protein 1, anticorps damage-specific DNA binding protein 1, anticorps DDB1, anticorps ddb1, anticorps LOC100187356, anticorps Ddb1, anticorps ddb-1

Sujet:

Background: Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.

Aliases: Damage specific DNA binding protein 1 antibody, Damage-specific DNA-binding protein 1 antibody, DDB 1 antibody, DDB p127 subunit antibody, Ddb1 antibody, DDB1_HUMAN antibody, DDBa antibody, DNA damage binding protein 1 antibody, DNA damage-binding protein 1 antibody, DNA damage-binding protein a antibody, HBV X-associated protein 1 antibody, UV damaged DNA binding factor antibody, UV damaged DNA binding protein 1 antibody, UV DDB 1 antibody, UV DDB1 antibody, UV-damaged DNA-binding factor antibody, UV-damaged DNA-binding protein 1 antibody, UV-DDB 1 antibody, X associated protein 1 antibody, XAP 1 antibody, XAP-1 antibody, XAP1 antibody, Xeroderma pigmentosum group E complementing protein antibody, Xeroderma pigmentosum group E-complementing protein antibody, XPCe antibody, XPE antibody, XPE BF antibody, XPE binding factor antibody, XPE-BF antibody, XPE-binding factor antibody

UniProt: Q16531

Pathways: Réparation de l'ADN