DDB2 anticorps (AA 1-185)

N° du produit ABIN7150128

Détail du produit anti-DDB2 anticorps

Antigène: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Épitope: AA 1-185

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human DNA damage-binding protein 2 protein (1-185AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DDB2

Antigène: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Autre désignation: DDB2 (DDB2 Produits)

Synonymes: anticorps 2610043A19Rik, anticorps si:dkey-45f10.3, anticorps DDBB, anticorps UV-DDB2, anticorps damage specific DNA binding protein 2, anticorps damage-specific DNA binding protein 2, anticorps DDB2, anticorps ddb2, anticorps Ddb2

Sujet:

Background: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

Aliases: damage-specific DNA binding protein 2 antibody, Damage-specific DNA-binding protein 2 antibody, DDB p48 subunit antibody, Ddb2 antibody, DDB2_HUMAN antibody, DDBb antibody, DNA damage-binding protein 2 antibody, UV-damaged DNA-binding protein 2 antibody, UV-DDB 2 antibody, Xeroderma pigmentosum group E protei antibody

UniProt: Q92466

Pathways: Réparation de l'ADN