Retinoblastoma Binding Protein 8 anticorps (AA 126-331)

N° du produit ABIN7150164

Détail du produit anti-Retinoblastoma Binding Protein 8 anticorps

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Épitope: AA 126-331

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Retinoblastoma Binding Protein 8 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human DNA endonuclease RBBP8 protein (126-331AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Retinoblastoma Binding Protein 8

Antigène: Retinoblastoma Binding Protein 8 (RBBP8)

Autre désignation: RBBP8 (RBBP8 Produits)

Synonymes: anticorps COM1, anticorps CTIP, anticorps JWDS, anticorps RIM, anticorps SAE2, anticorps SCKL2, anticorps 9930104E21Rik, anticorps CtIP, anticorps RBBP-8, anticorps RGD1308872, anticorps RBBP8, anticorps DKFZp469K0714, anticorps RB binding protein 8, endonuclease, anticorps retinoblastoma binding protein 8, endonuclease, anticorps retinoblastoma binding protein 8 L homeolog, anticorps retinoblastoma binding protein 8, anticorps RBBP8, anticorps Rbbp8, anticorps rbbp8.L, anticorps rbbp8

Sujet:

Background: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Aliases: COM1 antibody, COM1_HUMAN antibody, CtBP interacting protein antibody, CtBP-interacting protein antibody, CtIP antibody, DNA endonuclease RBBP8 antibody, JWDS antibody, RB binding protein 8 endonuclease antibody, RBBP-8 antibody, RBBP8 antibody, Retinoblastoma-binding protein 8 antibody, Retinoblastoma-interacting protein and myosin-like antibody, Rim antibody, SAE2 antibody, SCKL2 antibody, Sporulation in the absence of SPO11 protein 2 homolog antibody

UniProt: Q99708

Pathways: Cycle Cellulaire, Réparation de l'ADN