STT3B anticorps (AA 682-809)
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- Antigène Voir toutes STT3B Anticorps
- STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))
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Épitope
- AA 682-809
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp STT3B est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B protein (682-809AA)
- Isotype
- IgG
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- Indications d'application
- Recommended dilution: IHC:1:200-1:500,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))
- Autre désignation
- STT3B (STT3B Produits)
- Synonymes
- anticorps RGD1311563, anticorps 1300006C19Rik, anticorps Simp, anticorps SIMP, anticorps STT3-B, anticorps STT3B, catalytic subunit of the oligosaccharyltransferase complex, anticorps STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae), anticorps Stt3b, anticorps STT3B
- Sujet
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Background: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR \\\'Asp-38\\\' of TTR at \\\'Asn-118\\\', leading to its degradation.
Aliases: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B antibody, Homolog of yeast STT3 antibody, Oligosaccharyl transferase subunit STT3B antibody, SIMP antibody, source of immunodominant MHC associated peptides antibody, Source of immunodominant MHC-associated peptides homolog antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B (S. cerevisiae) antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B antibody, STT3-B antibody, Stt3b antibody, STT3B_HUMAN antibody
- UniProt
- Q8TCJ2
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