Mre11 anticorps (AA 1-205)

N° du produit ABIN7150624

Détail du produit anti-Mre11 anticorps

Antigène: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Épitope: AA 1-205

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Mre11 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Double-strand break repair protein MRE11A protein (1-205AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Mre11

Antigène: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Autre désignation: MRE11 (MRE11A Produits)

Synonymes: anticorps wu:faa63d12, anticorps zgc:64018, anticorps Mre11, anticorps Mre11b, anticorps ATLD, anticorps HNGS1, anticorps MRE11, anticorps MRE11B, anticorps MRE11 homolog A, double strand break repair nuclease, anticorps MRE11 homolog, double strand break repair nuclease, anticorps MRE11A homolog A, double strand break repair nuclease, anticorps mre11a, anticorps MRE11, anticorps Mre11a

Sujet:

Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3\\\'-5\\\' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

Aliases: AT like disease antibody, Ataxia telangiectasia disorder like antibody, ATLD antibody, DNA recombination and repair protein antibody, Double strand break repair protein MRE11A antibody, Double-strand break repair protein MRE11A antibody, endo/exonuclease Mre11 antibody, HNGS1 antibody, meiotic recombination (S. cerevisiae) 11 homolog A antibody, Meiotic recombination 11 homolog 1 antibody, meiotic recombination 11 homolog A (S. cerevisiae) antibody, Meiotic recombination 11 homolog A antibody, M mMRE11A antibody, Mre 11 antibody, MRE 11a antibody, MRE 11b antibody, MRE11 homolog 1 antibody, MRE11 homolog A antibody, MRE11 homolog double strand break repair nuclease antibody, MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody, MRE11 meiotic recombination 11 homolog A antibody, MRE11_HUMAN antibody, MRE11A antibody, MRE11b antibody, OTTHUMP00000236830 antibody, OTTHUMP00000236831 antibody, OTTHUMP00000236832 antibody, OTTHUMP00000236833 antibody

UniProt: P49959

Pathways: Réparation de l'ADN