DMRT1 anticorps (AA 195-363)
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- Antigène Voir toutes DMRT1 Anticorps
- DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))
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Épitope
- AA 195-363
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DMRT1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain, Souris
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)
- Isotype
- IgG
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- Indications d'application
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))
- Autre désignation
- DMRT1 (DMRT1 Produits)
- Synonymes
- anticorps DMT1, anticorps DMRT1, anticorps zgc:136676, anticorps dmrt1, anticorps dmrt1-alpha, anticorps dmt1, anticorps dmrt1-beta, anticorps xdmrt1, anticorps doublesex and mab-3 related transcription factor 1, anticorps doublesex and mab-3 related transcription factor 1 L homeolog, anticorps doublesex and mab-3 related transcription factor 1 S homeolog, anticorps DMRT1, anticorps Dmrt1, anticorps dmrt1, anticorps dmrt1.L, anticorps dmrt1.S
- Sujet
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Background: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
Aliases: CT154 antibody, DM domain expressed in testis 1 antibody, DM domain expressed in testis protein 1 antibody, DM domain gene expressed in testis antibody, DMRT 1 antibody, dmrt1 antibody, DMRT1_HUMAN antibody, DMT 1 antibody, DMT1 antibody, Doublesex and mab 3 related transcription factor 1 antibody, Doublesex- and mab-3-related transcription factor 1 antibody
- UniProt
- Q9Y5R6
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