HERC5 anticorps (AA 153-284)
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- Antigène Voir toutes HERC5 Anticorps
- HERC5 (Hect Domain and RLD 5 (HERC5))
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Épitope
- AA 153-284
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HERC5 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human E3 ISG15--protein ligase HERC5 protein (153-284AA)
- Isotype
- IgG
- Top Product
- Discover our top product HERC5 Anticorps primaire
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- HERC5 (Hect Domain and RLD 5 (HERC5))
- Autre désignation
- HERC5 (HERC5 Produits)
- Synonymes
- anticorps HERC5, anticorps CEB1, anticorps CEBP1, anticorps HECT and RLD domain containing E3 ubiquitin protein ligase 5, anticorps hect domain and RLD 5, anticorps HERC5
- Sujet
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Background: Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence, ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Aliases: CEB1 antibody, CEBP1 antibody, Cyclin E binding protein 1 antibody, Cyclin-E-binding protein 1 antibody, E3 ISG15--protein ligase HERC5 antibody, HECT domain and RCC1 like domain containing protein 5 antibody, HECT domain and RCC1-like domain-containing protein 5 antibody, Hect domain and RLD 5 antibody, HECT E3 ubiquitin ligase antibody, HERC5 antibody, HERC5_HUMAN antibody, Herc6 antibody
- UniProt
- Q9UII4
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