CHFR anticorps (AA 141-422)

N° du produit ABIN7151005

Détail du produit anti-CHFR anticorps

Antigène: CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))

Épitope: AA 141-422

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHFR est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase CHFR protein (141-422AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CHFR

Antigène: CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))

Autre désignation: CHFR (CHFR Produits)

Sujet:

Background: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the \\\'Lys-48\\\'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of \\\'Lys-63\\\'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at \\\'Lys-63\\\' are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Aliases: Checkpoint with forkhead and ring finger domains antibody, Checkpoint with forkhead and RING finger domains protein antibody, Chfr antibody, CHFR_HUMAN antibody, E3 ubiquitin protein ligase CHFR antibody, E3 ubiquitin-protein ligase CHFR antibody, EC 6.3.2. antibody, FLJ10796 antibody, FLJ33629 antibody, RING finger protein 196 antibody, RNF 116 antibody, RNF 196 antibody, RNF116 antibody, RNF196 antibody, Ubiquitin ligase protein antibody

UniProt: Q96EP1