Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

STUB1 anticorps (AA 1-48)

STUB1 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7151009
  • Antigène Voir toutes STUB1 Anticorps
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    Épitope
    • 15
    • 12
    • 8
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-48
    Reactivité
    • 74
    • 44
    • 40
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 67
    • 5
    • 2
    Lapin
    Clonalité
    • 63
    • 11
    Polyclonal
    Conjugué
    • 32
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp STUB1 est non-conjugé
    Application
    • 53
    • 25
    • 14
    • 13
    • 13
    • 11
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human E3 ubiquitin-protein ligase CHIP protein (1-48AA)
    Isotype
    IgG
    Top Product
    Discover our top product STUB1 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    Autre désignation
    STUB1 (STUB1 Produits)
    Synonymes
    anticorps CHIP, anticorps HSPABP2, anticorps NY-CO-7, anticorps SDCCAG7, anticorps UBOX1, anticorps 0610033N24Rik, anticorps 2210017D18Rik, anticorps 2310040B03Rik, anticorps AW046544, anticorps Chip, anticorps wu:fc22f04, anticorps zgc:56076, anticorps STUB1, anticorps chip, anticorps ATCHIP, anticorps CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN, anticorps carboxyl terminus of HSC70-interacting protein, anticorps STIP1 homology and U-box containing protein 1, anticorps STIP1 homology and U-Box containing protein 1, anticorps STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog, anticorps STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase, anticorps STIP1 homology and U box-containing protein 1, anticorps carboxyl terminus of HSC70-interacting protein, anticorps STUB1, anticorps Stub1, anticorps stub1, anticorps stub1.L, anticorps LOC100282870, anticorps CHIP
    Sujet

    Background: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at \\\'Lys-41\\\', \\\'Lys-61\\\' and \\\'Lys-81\\\', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).

    Aliases: Antigen NY CO 7 antibody, Antigen NY-CO-7 antibody, C terminus of Hsp70-interacting protein antibody, Carboxy terminus of Hsp70 interacting protein antibody, Carboxy terminus of Hsp70-interacting protein antibody, Carboxy terminus of Hsp70p interacting protein antibody, CHIP antibody, CHIP_HUMAN antibody, CLL associated antigen KW 8 antibody, CLL-associated antigen KW-8 antibody, E3 ubiquitin protein ligase CHIP antibody, E3 ubiquitin-protein ligase CHIP antibody, Heat shock protein A binding protein 2 (c terminal) antibody, HSPABP2 antibody, NY CO 7 antibody, PP1131 antibody, SDCCAG7 antibody, Serologically defined colon cancer antigen 7 antibody, STIP1 homology and U Box containing protein 1 antibody, STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody, STIP1 homology and U box-containing protein 1 antibody, STUB 1 antibody, STUB1 antibody, UBOX 1 antibody, UBOX1 antibody

    UniProt
    Q9UNE7
    Pathways
    Regulation of Hormone Metabolic Process, Response to Water Deprivation
Support technique