NEDD4-2 anticorps (AA 289-494) (HRP)
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- Antigène Voir toutes NEDD4-2 (NEDD4L) Anticorps
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
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Épitope
- AA 289-494
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NEDD4-2 est conjugé à/à la HRP
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human E3 ubiquitin-protein ligase NEDD4-like protein (289-494AA)
- Isotype
- IgG
- Top Product
- Discover our top product NEDD4L Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- Autre désignation
- NEDD4L (NEDD4L Produits)
- Synonymes
- anticorps NEDD4-2, anticorps NEDD4.2, anticorps RSP5, anticorps hNEDD4-2, anticorps nedd4, anticorps nedd4-2, anticorps NEDD4, anticorps Nedd4-2, anticorps 1300012C07Rik, anticorps Nedd4b, anticorps neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase, anticorps NEDD4L, anticorps neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog, anticorps neural precursor cell expressed, developmentally down-regulated gene 4-like, anticorps NEDD4L, anticorps LOC776799, anticorps nedd4l.S, anticorps Nedd4l
- Sujet
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Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5 (PubMed:26363003). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961).
Aliases: E3 ubiquitin protein ligase NEDD4 like protein antibody, E3 ubiquitin-protein ligase NEDD4-like antibody, KIAA0439 antibody, NED4L_HUMAN antibody, NEDD4 2 antibody, NEDD4 2c antibody, Nedd4-2 antibody, NEDD4-2a antibody, NEDD4.2 antibody, NEDD4b antibody, NEDD4L antibody, NEDD4La antibody, NEDD4Lb antibody, NEDD4Lc antibody, NEDD4Ld antibody, NEDD4Le antibody, NEDD4Lf antibody, NEDD4Lg antibody, NEDD4Lh antibody, NEDL3 antibody, Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody, Neural precursor cell expressed, developmentally down regulated 4 like antibody, RSP5 antibody, Ubiquitin protein ligase Rsp5 antibody
- UniProt
- Q96PU5
- Pathways
- Negative Regulation of Transporter Activity
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