NHLRC1 anticorps (AA 86-395) (HRP)

N° du produit ABIN7151091

Détail du produit anti-NHLRC1 anticorps (HRP)

Antigène: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Épitope: AA 86-395

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NHLRC1 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (86-395aa)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NHLRC1

Antigène: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Autre désignation: NHLRC1 (NHLRC1 Produits)

Synonymes: anticorps EPM2A, anticorps EPM2B, anticorps MALIN, anticorps bA204B7.2, anticorps AI505271, anticorps B230309E09Rik, anticorps Epm2b, anticorps malin-like, anticorps NHL repeat containing E3 ubiquitin protein ligase 1, anticorps NHL repeat containing 1, anticorps NHLRC1, anticorps Nhlrc1

Sujet:

Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Aliases: E3 ubiquitin-protein ligase NHLRC1 (EC 2.3.2.27) (Malin) (NHL repeat-containing protein 1) (RING-type E3 ubiquitin transferase NHLRC1), NHLRC1, EPM2B

UniProt: Q6VVB1