RNF126 anticorps (AA 39-225)

N° du produit ABIN7151134

Détail du produit anti-RNF126 anticorps

Antigène: RNF126 (Ring Finger Protein 126 (RNF126))

Épitope: AA 39-225

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF126 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RNF126

Antigène: RNF126 (Ring Finger Protein 126 (RNF126))

Autre désignation: RNF126 (RNF126 Produits)

Synonymes: anticorps 2610010O19Rik, anticorps ring finger protein 126, anticorps RNF126, anticorps Rnf126

Sujet:

Background: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates \\\'Lys-48\\\'- and \\\'Lys-63\\\'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

Aliases: E3 ubiquitin-protein ligase RNF126 antibody, FLJ20552 antibody, MGC1022 antibody, MGC14317 antibody, RING finger protein 126 antibody, RN126_HUMAN antibody, RNF 126 antibody, RNF126 antibody

UniProt: Q9BV68