RNF128 anticorps (AA 229-400)

N° du produit ABIN7151138

Détail du produit anti-RNF128 anticorps

Antigène: RNF128 (Ring Finger Protein 128 (RNF128))

Épitope: AA 229-400

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF128 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RNF128

Antigène: RNF128 (Ring Finger Protein 128 (RNF128))

Autre désignation: RNF128 (RNF128 Produits)

Synonymes: anticorps rnf128, anticorps wu:fb57h05, anticorps zgc:77843, anticorps 1300002C13Rik, anticorps AI987883, anticorps GRAIL, anticorps Greul1, anticorps RGD1566282, anticorps grail, anticorps greul1, anticorps ring finger protein 128a, anticorps ring finger protein 128, E3 ubiquitin protein ligase, anticorps ring finger protein 128, anticorps ring finger protein 128, E3 ubiquitin protein ligase L homeolog, anticorps rnf128a, anticorps RNF128, anticorps Rnf128, anticorps rnf128.L

Sujet:

Background: E3 ubiquitin-protein ligase that catalyzes \\\'Lys-48\\\'- and \\\'Lys-63\\\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \\\'Lys-48\\\' linkages and COR1A with \\\'Lys-63\\\' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm, sensitizes ectoderm to respond to neural-inducing signals.

Aliases: E3 ubiquitin protein ligase RNF128 antibody, E3 ubiquitin-protein ligase RNF128 antibody, FLJ23516 antibody, Gene related to anergy in lymphocytes protein antibody, GRAIL antibody, RING finger protein 128 antibody, RN128_HUMAN antibody, RNF128 antibody

UniProt: Q8TEB7