RNF34 anticorps (AA 1-220)

N° du produit ABIN7151192

Détail du produit anti-RNF34 anticorps

Antigène: RNF34 (Ring Finger Protein 34 (RNF34))

Épitope: AA 1-220

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF34 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RNF34

Antigène: RNF34 (Ring Finger Protein 34 (RNF34))

Autre désignation: RNF34 (RNF34 Produits)

Synonymes: anticorps CARP-1, anticorps CARP1, anticorps RFI, anticorps RIF, anticorps RIFF, anticorps hRFI, anticorps rnf34, anticorps AW061037, anticorps AW536122, anticorps BC004042, anticorps C88279, anticorps Momo, anticorps fi35g06, anticorps wu:fi35g06, anticorps zgc:114043, anticorps zgc:171755, anticorps ring finger protein 34, anticorps E3 ubiquitin-protein ligase RNF34, anticorps ring finger protein 34a, anticorps ring finger protein 34b, anticorps Residual feed intake, anticorps RNF34, anticorps rnf34, anticorps Rnf34, anticorps rnf34a, anticorps rnf34b, anticorps RFI

Sujet:

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate \\\'Lys-48\\\'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through \\\'Lys-48\\\'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Aliases: CARP 1 antibody, CARP-1 antibody, CARP1 antibody, Caspase regulator CARP1 antibody, Caspases-8 and -10-associated RING finger protein 1 antibody, E3 ubiquitin-protein ligase RNF34 antibody, FYVE-RING finger protein Momo antibody, hRFI antibody, Human RING finger homologous to inhibitor of apoptosis protein antibody, RFI antibody, RIF antibody, RIFF antibody, RING finger protein 34 antibody, RING finger protein RIFF antibody, RNF34 antibody, RNF34_HUMAN antibody

UniProt: Q969K3