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RNF4 anticorps (AA 1-103) (Biotin)

RNF4 Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7151195
  • Antigène Voir toutes RNF4 Anticorps
    RNF4 (Ring Finger Protein 4 (RNF4))
    Épitope
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-103
    Reactivité
    • 18
    • 3
    • 2
    Humain
    Hôte
    • 17
    • 2
    Lapin
    Clonalité
    • 18
    • 1
    Polyclonal
    Conjugué
    • 13
    • 3
    • 2
    • 1
    Cet anticorp RNF4 est conjugé à/à la Biotin
    Application
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA)
    Isotype
    IgG
    Top Product
    Discover our top product RNF4 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    RNF4 (Ring Finger Protein 4 (RNF4))
    Autre désignation
    RNF4 (RNF4 Produits)
    Synonymes
    anticorps SLX5, anticorps SNURF, anticorps AU018689, anticorps Gtrgeo8, anticorps ring finger protein 4, anticorps RNF4, anticorps Rnf4
    Sujet

    Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

    Aliases: E3 ubiquitin ligase RNF4 antibody, E3 ubiquitin protein ligase RNF4 antibody, Protein SNURF antibody, RES4 26 antibody, RING finger protein 4 antibody, Rnf4 antibody, RNF4_HUMAN antibody, SLX5 antibody, Small nuclear ring finger protein antibody, SNURF antibody

    UniProt
    P78317
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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