XIAP anticorps (AA 1-497)

N° du produit ABIN7151314

Détail du produit anti-XIAP anticorps

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Épitope: AA 1-497

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XIAP est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase XIAP protein (1-497AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur XIAP

Antigène: XIAP (X-Linked Inhibitor of Apoptosis (XIAP))

Autre désignation: XIAP (XIAP Produits)

Synonymes: anticorps API3, anticorps BIRC4, anticorps IAP-3, anticorps ILP1, anticorps MIHA, anticorps XLP2, anticorps hIAP-3, anticorps hIAP3, anticorps api3, anticorps birc4, anticorps ilp1, anticorps miha, anticorps xlp2, anticorps xxiap, anticorps 1110015C02Rik, anticorps Aipa, anticorps Api3, anticorps Birc4, anticorps IAP3, anticorps ILP-1, anticorps mXIAP, anticorps riap3, anticorps fb73d01, anticorps wu:fb73d01, anticorps zgc:91873, anticorps BIRC8, anticorps X-linked inhibitor of apoptosis, anticorps X-linked inhibitor of apoptosis L homeolog, anticorps XIAP, anticorps xiap, anticorps xiap.L, anticorps Xiap

Sujet:

Background: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Aliases: AP 13 antibody, API3 antibody, Apoptosis Inhibitor 3 antibody, Baculoviral IAP repeat containing 4 antibody, Baculoviral IAP Repeat Containing Protein 4 antibody, Baculoviral IAP repeat-containing protein 4 antibody, BIRC 4 antibody, BIRC4 antibody, E3 ubiquitin-protein ligase XIAP antibody, hIAP-3 antibody, hIAP3 antibody, HILP antibody, IAP 3 antibody, IAP like protein antibody, IAP-3 antibody, IAP-like protein antibody, IAP3 antibody, ILP 1 antibody, ILP antibody, ILP1 antibody, Inhibitor of apoptosis protein 3 antibody, Inhibitor of Apoptosis X Linked antibody, Mammalian IAP Homologue A antibody, MIHA antibody, X linked IAP antibody, X linked inhibitor of apoptosis antibody, X linked inhibitor of apoptosis E3 ubiquitin protein ligase antibody, X linked inhibitor of apoptosis protein antibody, X-linked IAP antibody, x-linked inhibitor of apopotosis proteins antibody, X-linked inhibitor of apoptosis protein antibody, Xiap antibody, XIAP_HUMAN antibody, XLP2 antibody

UniProt: P98170

Pathways: Apoptose, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis