EPH Receptor A7 anticorps (AA 28-182)

N° du produit ABIN7151851

Détail du produit anti-EPH Receptor A7 anticorps

Antigène: EPH Receptor A7 (EPHA7)

Épitope: AA 28-182

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A7 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ephrin type-A receptor 7 protein (28-182AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPH Receptor A7

Antigène: EPH Receptor A7 (EPHA7)

Autre désignation: EPHA7 (EPHA7 Produits)

Synonymes: anticorps fc51g03, anticorps wu:fc51g03, anticorps si:dkey-23k6.1, anticorps EHK3, anticorps HEK11, anticorps Cek11, anticorps Ebk, anticorps Ehk3, anticorps Hek11, anticorps Mdk1, anticorps CEPHA7, anticorps EPH receptor A7, anticorps eph receptor A7, anticorps ephrin type-B receptor 1-B, anticorps Eph receptor A7, anticorps EPHA7, anticorps epha7, anticorps LOC100166161, anticorps Epha7

Sujet:

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Aliases: Cek 11 antibody, Developmental kinase 1 antibody, EBK antibody, EHK-3 antibody, EHK3 antibody, EK11 antibody, Embryonic brain kinase antibody, EPH homology kinase 3 antibody, EPH-like kinase 11 antibody, Epha7 antibody, EPHA7_HUMAN antibody, Ephrin receptor Eph A7 antibody, Ephrin type A receptor 7 antibody, Ephrin type-A receptor 7 antibody, hEK11 antibody, MDK 1 antibody, Receptor protein tyrosine kinase HEK 11 antibody, Tyrosine protein kinase receptor EHK 3 antibody

UniProt: Q15375

Pathways: Signalisation RTK