DIS3 anticorps (AA 30-187) (Biotin)

N° du produit ABIN7152298

Détail du produit anti-DIS3 anticorps (Biotin)

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Épitope: AA 30-187

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIS3 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Exosome complex exonuclease RRP44 protein (30-187AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DIS3

Antigène: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Autre désignation: DIS3 (DIS3 Produits)

Synonymes: anticorps EXOSC11, anticorps KIAA1008, anticorps RP11-342J4.3, anticorps RRP44, anticorps bA555G22.1, anticorps dis3p, anticorps DIS3, anticorps 2810028N01Rik, anticorps RGD1304646, anticorps wu:fb08g12, anticorps dis3, anticorps DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, anticorps DIS3 exosome endoribonuclease and 3'-5' exoribonuclease, anticorps DIS3, anticorps Dis3, anticorps dis3, anticorps dis3.L

Sujet:

Background: Putative catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3\'-5\' exonuclease and endonuclease activities.

Aliases: 2810028N01Rik antibody, bA555G22 antibody, Dis3 antibody, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 mitotic control homolog (S. cerevisiae) antibody, DIS3 mitotic control homolog antibody, DIS3 mitotic control, S. cerevisiae, homolog of antibody, dis3p antibody, EXOSC11 antibody, Exosome complex exonuclease RRP44 antibody, exosome component 11 antibody, KIAA1008 antibody, Mitotic control protein dis3 homolog antibody, Protein DIS3 homolog antibody, Ribosomal RNA processing protein 44 antibody, Ribosomal RNA processing protein 44, S. cerevisiae, homolog of antibody, Ribosomal RNA-processing protein 44 antibody, RP11-342J4.3 antibody, RRP44 antibody, RRP44_HUMAN antibody

UniProt: Q9Y2L1