EXOSC1 anticorps (AA 587-762) (Biotin)
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- Antigène Voir toutes EXOSC1 Anticorps
- EXOSC1 (Exosome Component 1 (EXOSC1))
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Épitope
- AA 587-762
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EXOSC1 est conjugé à/à la Biotin
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Exosome component 10 protein (587-762AA)
- Isotype
- IgG
- Top Product
- Discover our top product EXOSC1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- EXOSC1 (Exosome Component 1 (EXOSC1))
- Autre désignation
- EXOSC1 (EXOSC1 Produits)
- Synonymes
- anticorps MGC86284, anticorps CGI-108, anticorps CSL4, anticorps Csl4p, anticorps SKI4, anticorps Ski4p, anticorps hCsl4p, anticorps p13, anticorps 2610035C18Rik, anticorps 2610104C07Rik, anticorps 2610312F07Rik, anticorps AI447561, anticorps exosome component 1, anticorps exosome component 1 L homeolog, anticorps EXOSC1, anticorps exosc1.L, anticorps exosc1, anticorps PTRG_05845, anticorps Exosc1
- Sujet
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Background: Putative catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3\'-5\' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.
Aliases: Autoantigen PM/Scl 2 antibody, Exosc10 antibody, Exosome component 10 antibody, EXOSX_HUMAN antibody, P100 polymyositis scleroderma overlap syndrome associated autoantigen antibody, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody, p2 antibody, p3 antibody, p4 antibody, PM Scl antibody, PM/Scl 100 antibody, PM/Scl-100 antibody, PMSCL antibody, PMSCL2 antibody, Polymyositis/scleroderma autoantigen 100 kDa antibody, Polymyositis/scleroderma autoantigen 2 100 kDa antibody, Polymyositis/scleroderma autoantigen 2 antibody, RRP6 antibody, Rrp6p antibody
- UniProt
- Q01780
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