FBXO9 anticorps (AA 13-111)

N° du produit ABIN7152451

Détail du produit anti-FBXO9 anticorps

Antigène: FBXO9 (F-Box Protein 9 (FBXO9))

Épitope: AA 13-111

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXO9 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human F-box only protein 9 protein (13-111AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FBXO9

Antigène: FBXO9 (F-Box Protein 9 (FBXO9))

Autre désignation: FBXO9 (FBXO9 Produits)

Synonymes: anticorps fbxo9, anticorps MGC75727, anticorps FBXO9, anticorps fbx9, anticorps FBX9, anticorps NY-REN-57, anticorps VCIA1, anticorps dJ341E18.2, anticorps wu:fc79g12, anticorps zgc:56212, anticorps zgc:77654, anticorps 9030401P18Rik, anticorps AA986398, anticorps F-box protein 9, anticorps F-box only protein 9, anticorps f-box protein 9, anticorps F-box protein 9 L homeolog, anticorps fbxo9, anticorps FBXO9, anticorps CpipJ_CPIJ012920, anticorps Tsp_03945, anticorps fbx9, anticorps Fbxo9, anticorps fbxo9.L

Sujet:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Aliases: Cross-immune reaction antigen 1 antibody, dJ341E18.2 antibody, DKFZp434C0118 antibody, F-box only protein 9 antibody, Fbp24 antibody, FBX09 antibody, FBX9 antibody, FBX9_HUMAN antibody, Fbxo9 antibody, KIAA0936 antibody, NY REN 57 antibody, OTTHUMP00000016628 antibody, OTTHUMP00000016629 antibody, OTTHUMP00000214588 antibody, Renal carcinoma antigen NY-REN-57 antibody, VCIA1 antibody

UniProt: Q9UK97