FBXL2 anticorps (AA 1-423) (HRP)

N° du produit ABIN7152475

Détail du produit anti-FBXL2 anticorps (HRP)

Antigène: FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))

Épitope: AA 1-423

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXL2 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FBXL2

Antigène: FBXL2 (F-Box and Leucine-Rich Repeat Protein 2 (FBXL2))

Autre désignation: FBXL2 (FBXL2 Produits)

Synonymes: anticorps FBL2, anticorps FBL3, anticorps 2810423A21Rik, anticorps Fbl3, anticorps RGD1562243, anticorps fbxl20, anticorps sb:cb783, anticorps zgc:73374, anticorps Fbl2, anticorps Fbxl2, anticorps F-box and leucine rich repeat protein 2, anticorps F-box and leucine-rich repeat protein 2, anticorps F-box and leucine-rich repeat protein 20, anticorps FBXL2, anticorps Fbxl2, anticorps fbxl2, anticorps Fbxl20

Sujet:

Background: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Aliases: DKFZP564P0622 antibody, F box and leucine rich repeat protein 2 antibody, F box protein containing leucine rich repeats antibody, F box protein FBL2/FBL3 antibody, F box/LRR repeat protein 2 antibody, F-box and leucine-rich repeat protein 2 antibody, F-box protein FBL2/FBL3 antibody, F-box/LRR-repeat protein 2 antibody, FBL 2 antibody, FBL 3 antibody, FBL2 antibody, FBL3 antibody, FBXL 2 antibody, FBXL2 antibody, FBXL2_HUMAN antibody

UniProt: Q9UKC9