FBXW7 anticorps (AA 1-707) (HRP)
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- Antigène Voir toutes FBXW7 Anticorps
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Épitope
- AA 1-707
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXW7 est conjugé à/à la HRP
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Application
- ELISA
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA)
- Isotype
- IgG
- Top Product
- Discover our top product FBXW7 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Autre désignation
- FBXW7 (FBXW7 Produits)
- Synonymes
- anticorps cdc4, anticorps AGO, anticorps CDC4, anticorps FBW6, anticorps FBW7, anticorps FBX30, anticorps FBXO30, anticorps FBXW6, anticorps SEL-10, anticorps SEL10, anticorps hAgo, anticorps hCdc4, anticorps 1110001A17Rik, anticorps Cdc4, anticorps Fbw7, anticorps Fbwd6, anticorps Fbx30, anticorps Fbxo30, anticorps Fbxw6, anticorps F-box and WD repeat domain containing 7, anticorps F-box and WD-40 domain protein 7, anticorps Fbxw7, anticorps FBXW7, anticorps fbxw7
- Sujet
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Background: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
Aliases: AGO antibody, Archipelago antibody, Archipelago homolog antibody, Archipelago, Drosophila, homolog of antibody, CDC4 antibody, CDC4, S.cerevisiae, homolog of antibody, DKFZp686F23254 antibody, F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody, F box and WD 40 domain protein 7 antibody, F box and WD repeat domain containing 7 antibody, F box protein FBW7 antibody, F box protein FBX30 antibody, F box protein SEL 10 antibody, F box protein SEL10 antibody, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody, F-box and WD-40 domain-containing protein 7 antibody, F-box protein FBX30 antibody, F-box/WD repeat-containing protein 7 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, FBXW7 antibody, FBXW7_HUMAN antibody, FLJ16457 antibody, hAgo antibody, hCdc4 antibody, Homolog of C elegans sel 10 antibody, Homolog of C.elegans sel10 antibody, SEL 10 antibody, SEL-10 antibody, SEL10 antibody
- UniProt
- Q969H0
- Pathways
- Signalisation Notch, EGFR Signaling Pathway
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