FAN1 anticorps (AA 167-373) (Biotin)

N° du produit ABIN7152567

Détail du produit anti-FAN1 anticorps (Biotin)

Antigène: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Épitope: AA 167-373

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAN1 est conjugé à/à la Biotin

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Fanconi-associated nuclease 1 protein (167-373AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FAN1

Antigène: FAN1 (FANCD2/FANCI-Associated Nuclease 1 (FAN1))

Autre désignation: FAN1 (FAN1 Produits)

Synonymes: anticorps KIAA1018, anticorps KMIN, anticorps MTMR15, anticorps 6030441H18Rik, anticorps Mtmr15, anticorps fi39f01, anticorps mtmr15, anticorps si:ch211-163b1.2, anticorps si:ch211-201b11.2, anticorps wu:fd06a07, anticorps wu:fi39f01, anticorps RGD1566323, anticorps FANCD2 and FANCI associated nuclease 1, anticorps FANCD2/FANCI-associated nuclease 1, anticorps FAN1, anticorps Fan1, anticorps fan1

Sujet:

Background: Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5\'-3\' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3\'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5\'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3\' flap (PubMed:25430771). Also has endonuclease activity toward 5\'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Aliases: 6030441H18Rik antibody, Coiled coil domain containing protein MTMR15 antibody, DKFZp451H236 antibody, DKFZp686K16147 antibody, FAN1 antibody, FAN1_HUMAN antibody, FANCD2 and FANCI associated nuclease 1 antibody, FANCD2/FANCI associated nuclease 1 antibody, FANCD2/FANCI-associated nuclease 1 antibody, Fanconi associated nuclease 1 antibody, Fanconi-associated nuclease 1 antibody, hFAN1 antibody, KIAA1018 antibody, KMIN antibody, MTMR 15 antibody, MTMR15 antibody, Myotubularin related protein 15 antibody, Myotubularin-related protein 15 antibody

UniProt: Q9Y2M0

Pathways: Réparation de l'ADN