FZR1 anticorps (AA 1-493)

N° du produit ABIN7152956

Détail du produit anti-FZR1 anticorps

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Épitope: AA 1-493

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Fizzy-related protein homolog protein (1-493AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FZR1

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Autre désignation: FZR1 (FZR1 Produits)

Synonymes: anticorps CDH1-C, anticorps FYR, anticorps FZR, anticorps CDH1, anticorps fzr1, anticorps CDC20C, anticorps FZR2, anticorps HCDH, anticorps HCDH1, anticorps AW108046, anticorps Cdh1, anticorps Fyr, anticorps zgc:55450, anticorps fizzy and cell division cycle 20 related 1, anticorps fizzy/cell division cycle 20 related 1, anticorps fizzy-related protein homolog, anticorps fizzy/cell division cycle 20 related 1 (Drosophila), anticorps fizzy/cell division cycle 20 related 1a, anticorps Fzr1, anticorps CDH1-C, anticorps FZR1, anticorps LOC100027495, anticorps LOC100179951, anticorps fzr1a

Sujet:

Background: Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Aliases: CDC20 like 1b antibody, CDC20 like protein 1 antibody, CDC20-like protein 1 antibody, CDC20C antibody, CDH1 antibody, Cdh1/Hct1 homolog antibody, Fizzy related protein 1 antibody, Fizzy related protein antibody, Fizzy related protein homolog antibody, Fizzy-related protein homolog antibody, Fizzy/cell division cycle 20 related 1 antibody, FYR antibody, FZR 1 antibody, FZR 2 antibody, Fzr antibody, FZR_HUMAN antibody, Fzr1 antibody, Fzr1 protein antibody, FZR2 antibody, HCDH 1 antibody, HCDH antibody, hCDH1 antibody, KIAA1242 antibody

UniProt: Q9UM11

Pathways: DNA Replication, Synthesis of DNA