FZD1 anticorps (AA 73-322)

N° du produit ABIN7153175

Détail du produit anti-FZD1 anticorps

Antigène: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Épitope: AA 73-322

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Frizzled-1 protein (73-322AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FZD1

Antigène: FZD1 (Fzd1) (Frizzled Family Receptor 1 (Fzd1))

Autre désignation: FZD1 (Fzd1 Produits)

Synonymes: anticorps CG17697, anticorps CG3646, anticorps DFZ1, anticorps DFz, anticorps DFz1, anticorps Dfz1, anticorps Dm Fz1, anticorps Dmel\\CG17697, anticorps FZ, anticorps Frz, anticorps Fz, anticorps Fz1, anticorps frz, anticorps fz1, anticorps fz[[1]], anticorps Fz-1, anticorps cFz-1, anticorps Xfrizzled-1, anticorps frizzled1, anticorps frz-1, anticorps frz1, anticorps fzd1-A, anticorps AW227548, anticorps FZ-1, anticorps frizzled, anticorps frizzled class receptor 1, anticorps frizzled class receptor 1 L homeolog, anticorps fz, anticorps FZD1, anticorps Fzd1, anticorps fzd1.L

Sujet:

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Aliases: Chfz-1 antibody, Dfrizzled-1 antibody, DKFZp564G072 antibody, FLJ95923 antibody, Frizzled 1 antibody, Frizzled homolog 1 (Drosophila) antibody, Frizzled homolog 1 antibody, Frizzled-1 antibody, Fz receptor 1 antibody, Fz-1 antibody, Fz1 antibody, FZD1 antibody, FZD1_HUMAN antibody, FzE1 antibody, hFz1 antibody, Rfz1 antibody, Wnt receptor antibody, Xfrizzled-1 antibody

UniProt: Q9UP38

Pathways: Signalisation WNT, Asymmetric Protein Localization