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GRK5 anticorps (AA 406-590) (HRP)

GRK5 Reactivité: Humain ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN7153300
  • Antigène Voir toutes GRK5 Anticorps
    GRK5 (G Protein-Coupled Receptor Kinase 5 (GRK5))
    Épitope
    • 9
    • 8
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 406-590
    Reactivité
    • 47
    • 30
    • 20
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 45
    • 2
    • 1
    Lapin
    Clonalité
    • 46
    • 2
    Polyclonal
    Conjugué
    • 28
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GRK5 est conjugé à/à la HRP
    Application
    • 33
    • 27
    • 22
    • 8
    • 3
    • 2
    • 2
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human G protein-coupled receptor kinase 5 protein (406-590AA)
    Isotype
    IgG
    Top Product
    Discover our top product GRK5 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    GRK5 (G Protein-Coupled Receptor Kinase 5 (GRK5))
    Autre désignation
    GRK5 (GRK5 Produits)
    Synonymes
    anticorps GPRK5, anticorps Gprk5, anticorps si:dkey-171l20.1, anticorps GRK5, anticorps DKFZp468J1119, anticorps grk5, anticorps G protein-coupled receptor kinase 5, anticorps G protein-coupled receptor kinase 5 L homeolog, anticorps GRK5, anticorps Grk5, anticorps grk5, anticorps grk5.L
    Sujet

    Background: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

    Aliases: FLJ39780 antibody, FP2025 antibody, G protein coupled receptor kinase 5 antibody, G protein coupled receptor kinase GRK5 antibody, G protein-coupled receptor kinase 5 antibody, G protein-coupled receptor kinase GRK5 antibody, GPRK5 antibody, GRK-pan antibody, GRK5 antibody, GRK5_HUMAN antibody, Pan-GRK antibody

    UniProt
    P34947
    Pathways
    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
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