Cyclin D2 anticorps (AA 1-289)
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- Antigène Voir toutes Cyclin D2 (CCND2) Anticorps
- Cyclin D2 (CCND2)
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Épitope
- AA 1-289
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cyclin D2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- Antigen Affinity purified
- Immunogène
- Recombinant Human G1/S-specific cyclin-D2 protein (1-289AA)
- Isotype
- IgG
- Top Product
- Discover our top product CCND2 Anticorps primaire
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- Indications d'application
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:500, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- Cyclin D2 (CCND2)
- Autre désignation
- CCND2 (CCND2 Produits)
- Sujet
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Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Aliases: CCND 2 antibody, ccnd2 antibody, CCND2_HUMAN antibody, CyclinD2 antibody, G1/S specific cyclin D2 antibody, G1/S-specific cyclin-D2 antibody, KIAK0002 antibody, MGC102758 antibody, MPPH3 antibody
- UniProt
- P30279
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases
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