GRHL3 anticorps (AA 31-182)

N° du produit ABIN7154380

Détail du produit anti-GRHL3 anticorps

Antigène: GRHL3 (Grainyhead-Like 3 (GRHL3))

Épitope: AA 31-182

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRHL3 est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Grainyhead-like protein 3 homolog protein (31-182AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur GRHL3

Antigène: GRHL3 (Grainyhead-Like 3 (GRHL3))

Autre désignation: GRHL3 (GRHL3 Produits)

Synonymes: anticorps GRHL3, anticorps SOM, anticorps TFCP2L4, anticorps AI561912, anticorps Get1, anticorps Som, anticorps Tfcp2l4, anticorps ct, anticorps grainyhead like transcription factor 3, anticorps grainyhead-like 3 (Drosophila), anticorps grainyhead-like transcription factor 3, anticorps GRHL3, anticorps Grhl3

Sujet:

Background: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5\\\'-AACCGGTT-3\\\' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122).

Aliases: Drosophila antibody, Grainyhead like 3 antibody, Grainyhead like protein 3 homolog antibody, Grainyhead-like protein 3 homolog antibody, grhl3 antibody, GRHL3_HUMAN antibody, Sister of mammalian grainyhead antibody, Sister of mammalian grainyhead protein antibody, SOM antibody, TFCP2L4 antibody, Transcription factor CP2 like 4 antibody, Transcription factor CP2-like 4 antibody

UniProt: Q8TE85