SETDB1 anticorps (AA 1-397)

N° du produit ABIN7155521

Détail du produit anti-SETDB1 anticorps

Antigène: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Épitope: AA 1-397

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SETDB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Rat

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Histone-lysine N-methyltransferase SETDB1 protein (1-397AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SETDB1

Antigène: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Autre désignation: SETDB1 (SETDB1 Produits)

Synonymes: anticorps ESET, anticorps H3-K9-HMTase4, anticorps KG1T, anticorps KMT1E, anticorps TDRD21, anticorps AU022152, anticorps mKIAA0067, anticorps SETDB1, anticorps NV10069, anticorps fc07d03, anticorps si:ch211-81a5.6, anticorps wu:fc07d03, anticorps im:7143091, anticorps wu:fa04a12, anticorps wu:fj80h02, anticorps zgc:152899, anticorps SET domain bifurcated 1, anticorps SET domain, bifurcated 1, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11, anticorps histone-lysine N-methyltransferase SETDB1, anticorps SET domain, bifurcated 1a, anticorps SET domain bifurcated 1 L homeolog, anticorps SET domain, bifurcated 1b, anticorps SETDB1, anticorps Setdb1, anticorps MLLT11, anticorps LOC100120014, anticorps LOC100461671, anticorps setdb1a, anticorps setdb1.L, anticorps setdb1b

Sujet:

Background: Histone methyltransferase that specifically trimethylates \\\'Lys-9\\\' of histone H3. H3 \\\'Lys-9\\\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 \\\'Lys-9\\\' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone \\\'Lys-9\\\' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.

Aliases: AU022152 antibody, EC 2.1.1.43 antibody, ERG-associated protein with SET domain antibody, ESET antibody, H3 K9 HMTase 4 antibody, H3-K9-HMTase 4 antibody, H3-K9-HMTase4 antibody, Histone H3 K9 methyltransferase 4 antibody, Histone H3-K9 methyltransferase 4 antibody, Histone-lysine N-methyltransferase SETDB1 antibody, KG1T antibody, KIAA0067 antibody, KMT1E antibody, Lysine N-methyltransferase 1E antibody, MGC90670 antibody, mKIAA0067 antibody, SET domain bifurcated 1 antibody, Set domain protein, bifurcated, 1 antibody, SETB1_HUMAN antibody, Setdb1 antibody

UniProt: Q15047