SUV39H1 anticorps (AA 179-412)

N° du produit ABIN7155525

Détail du produit anti-SUV39H1 anticorps

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Épitope: AA 179-412

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUV39H1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Histone-lysine N-methyltransferase SUV39H1 protein (179-412AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SUV39H1

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Autre désignation: SUV39H1 (SUV39H1 Produits)

Synonymes: anticorps H3-K9-HMTase 1, anticorps KMT1A, anticorps MG44, anticorps SUV39H, anticorps AI852103, anticorps AL022883, anticorps DXHXS7466e, anticorps mIS6, anticorps RGD1565028, anticorps kmt1a, anticorps suv39h, anticorps fe02c04, anticorps suv39h1, anticorps wu:fe02c04, anticorps zgc:101027, anticorps fe47h06, anticorps wu:fb18a10, anticorps wu:fe47h06, anticorps zgc:136593, anticorps suppressor of variegation 3-9 homolog 1, anticorps suppressor of variegation 3-9 homolog 1 (Drosophila), anticorps suppressor of variegation 3-9 homolog 1 L homeolog, anticorps suppressor of variegation 3-9 homolog 1a, anticorps suppressor of variegation 3-9 homolog 1b, anticorps SUV39H1, anticorps Suv39h1, anticorps suv39h1.L, anticorps suv39h1a, anticorps suv39h1b

Sujet:

Background: Histone methyltransferase that specifically trimethylates \'Lys-9\' of histone H3 using monomethylated H3 \'Lys-9\' as substrate. Also weakly methylates histone H1 (in vitro). H3 \'Lys-9\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 \'Lys-9\' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at \'Lys-9\' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 \'Lys-9\' trimethylation.

Aliases: H3 K9 HMTase1 antibody, H3-K9-HMTase 1 antibody, Histone H3-K9 methyltransferase 1 antibody, Histone H3-K9 methyltransferase1 antibody, Histone lysine N methyltransferase, H3 lysine 9 specific 1 antibody, Histone-lysine N-methyltransferase SUV39H1 antibody, KMT1 A antibody, KMT1A antibody, Lysine N methyltransferase 1A antibody, Lysine N-methyltransferase 1A antibody, MG44 antibody, mIS6 antibody, Position-effect variegation 3-9 homolog antibody, Su(var)3 9 homolog 1 antibody, Su(var)3-9 homolog 1 antibody, Suppressor of variegation 3 9 homolog 1 (Drosophila) antibody, Suppressor of variegation 3-9 homolog 1 antibody, SUV39 H1 antibody, SUV39H antibody, SUV39H1 antibody, SUV91_HUMAN antibody

UniProt: O43463